Research Achievements

January 26, 2017  PRESS RELEASE

New Insights into Brain Circuit for Hunger Responses during Starvation

Researchers uncover mechanism by which hypothalamic neural signaling drives hunger responses to survive starvation.

 

Figure: The empty stomach releases the hormone called ghrelin.  By receiving ghrelin, the hypothalamus in the brain senses hunger and produces "hunger signaling" through the action of neuropeptide Y (NPY).  The hunger signaling activates neurons in the reticular formation of the medulla oblongata, which then inhibit sympathetic output to reduce metabolic heat production and simultaneously provide masticatory motor rhythm to facilitate feeding. © 2017 Yoshiko Nakamura

 

Nagoya, Japan - The human body responds to starving conditions, such as famine, to promote the chance of survival. It reduces energy expenditure by stopping heat production and promotes feeding behavior. These "hunger responses" are activated by the feeling of hunger in the stomach and are controlled by neuropeptide Y (NPY) signals released by neurons in the hypothalamus. However, how NPY signaling in the hypothalamus elicits the hunger responses has remained unknown.

 

Sympathetic motor neurons in the medulla oblongata are responsible for heat production by brown adipose tissue (BAT). Researchers centered at Nagoya University have now tested whether the heat-producing neurons respond to the same hypothalamic NPY signals that control hunger responses. They injected NPY into the hypothalamus of rats and tested the effect on heat production. Under normal conditions, blocking inhibitory GABAergic receptors or stimulating excitatory glutamatergic receptors in the sympathetic motor neurons induced heat production in BAT. After NPY injection, stimulating glutamatergic receptors did not produce heat, but inhibiting GABAergic receptors did. The study was recently reported in Cell Metabolism.

 

"This indicated that hypothalamic NPY signals prevent BAT thermogenesis by using inhibitory GABAergic inputs to sympathetic motor neurons," study lead author Yoshiko Nakamura says.

 

Retrograde and anterograde tracing with fluorescent dyes revealed which brain region provided the inhibitory GABAergic inputs to heat-producing motor neurons.

 

"Tracing experiments showed that sympathetic motor neurons are directly innervated by GABAergic inputs from reticular nuclei in the medulla oblongata," corresponding author Kazuhiro Nakamura explains, "selective activation of these GABAergic reticular neurons inhibits BAT thermogenesis."

 

The researchers' further findings showed that GABAergic inputs from medullary reticular neurons are involved in hypothalamic NPY-mediated inhibition of heat production in BAT. This hunger response circuit probably explains why anorexic individuals suffer from hypothermia.

 

Interestingly, stimulation of these medullary reticular neurons prompted rats to begin chewing and feeding. This effect was similar to injecting NPY into the hypothalamus, suggesting that hypothalamic NPY signaling activates reticular neurons in the medulla oblongata to promote feeding and mastication during the hunger response.

 

Abnormal activation of these neurons under non-starved conditions may contribute to obesity. Understanding these mechanisms could lead to development of more effective treatments for obesity.

 

The novel brain circuit for hunger responses is illustrated in the accompanying figure.

 

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The article, "Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication" was published in Cell Metabolism at DOI: http://dx.doi.org/10.1016/j.cmet.2016.12.002

 

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Authors: Assistant Prof. Yoshiko Nakamura and Prof. Kazuhiro Nakamura, Department of Integrative Physiology, Nagoya University Graduate School of Medicine, and their international research group including Gunma University and Oregon Health & Science University 

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More details (PDF)

 

Lab. of Prof. Nakamura, Department of Integrative Physiology, Nagoya University Graduate School of Medicine

 

Media Coverage:

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MedicalXpress

The Medical News

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Funding: This study was supported by the Funding Program for Next Generation World-Leading Researchers from the Japan Society for the Promotion of Science, by Grants-in-Aid for Scientific Research and a Grant-in-Aid for Scientific Research on Innovative Areas (Comprehensive Brain Science Network) from the MEXT of Japan, by a U.S. NIH grant, and by grants from the Takeda Science Foundation, Nakajima Foundation, Uehara Memorial Foundation, Brain Science Foundation, and Kowa Life Science Foundation.

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