Glycans, the sugar chains that cover the surface of cells in our body, play an essential role in determining our cells’ unique characteristics and regulating intercellular communication. These complex molecules also enable cells to recognize extracellular substances, such as neighboring cells, pathogens, and other molecules, making them critical to a range of physiological processes and diseases, including immunity, neural functions, aging, infection, tumor growth, and dementia. Despite their importance, glycans remain largely understudied. However, glycoscience research has already led to important advances in modern medicine, including the development of glycan-targeted drugs like Tamiflu and the cancer treatment via antibodies that have modified glycans.
The Institute for Glyco-core Research (iGCORE) was established to address these gaps in glycoscience research and promote a better understanding of the essential role glycans play in life processes. Through interdisciplinary collaboration among scientists with expertise in chemistry, biochemistry, medicine, and imaging, iGCORE aims to shed light on the functions and physical properties of glycans, as well as the properties of assembled glycans. By overcoming the major challenges of glycoscience research, we can ultimately enhance our understanding of the fundamental nature of living systems and improve medical care.